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フーディアの実験

ここに書かれている療法は病気の診断・治療、症状の改善を目的とするものでなく米国、日本で報告されたものをまとめたものです。

病気診断治療を目的とする場合は医師にまず相談ください。

私どもの顧問医師を紹介する場合や適切な医師を紹介することもあります。

フーディアの実験

Brain Res. 2004 Sep 10;1020(1-2):1-11. Related Articles, Links

Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: studies of the anorectic mechanism of a plant steroidal glycoside.

MacLean DB, Luo LG.

Division of Endocrinology, Hallett Center for Diabetes and Endocrinology, Brown Medical School, Coro Building Providence, RI 02903, USA. david_b_maclean@brown.edu

A steroidal glycoside with anorectic activity in animals, termed P57AS3 (P57), was isolated from Hoodia gordonii and found to have homologies to the steroidal core of cardiac glycosides. Intracerebroventricular (i.c.v.) injections of the purified P57AS3 demonstrated that the compound has a likely central (CNS) mechanism of action. There is no evidence of P57AS3 binding to or altering activity of known receptors or proteins, including Na/K-ATPase, the putative target of cardiac glycosides. The studies demonstrated that the compound increases the content of ATP by 50-150% in hypothalamic neurons. In addition, third ventricle (i.c.v.) administration of P57, which reduces subsequent 24-h food intake by 40-60%, also increases ATP content in hypothalamic slice punches removed at 24 h following the i.c.v. injections. In related studies, in pair fed rats fed a low calorie diet for 4 days, the content of ATP in the hypothalami of control i.c.v. injected animals fell by 30-50%, which was blocked by i.c.v. injections of P57AS3. With growing evidence of metabolic or nutrient-sensing by the hypothalamus, ATP may be a common currency of energy sensing, which in turn may trigger the appropriate neural, endocrine and appetitive responses as similar to other fundamental hypothalamic homeostatic centers for temperature and osmolarity.

PMID: 15312781 [PubMed - indexed for MEDLINE]

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